> ## Documentation Index
> Fetch the complete documentation index at: https://docs.purna.ai/llms.txt
> Use this file to discover all available pages before exploring further.

# Database search

> Query genomic, literature, pathway, protein, and drug databases from chat.

Purna connects to scientific databases so you can look up genes, variants, diseases, pathways, proteins, drugs, and literature without leaving the conversation. Ask naturally, and Purna selects the relevant tools and sources.

## Supported source areas

<AccordionGroup>
  <Accordion title="Gene and variant databases" icon="dna">
    Query gene function, transcripts, variant identifiers, clinical significance, population frequencies, and known disease associations.

    **Example queries:**

    * "What is known about BRCA1 c.68\_69delAG?"
    * "Compare ClinVar and gnomAD evidence for this variant."
    * "Which genes are most associated with dilated cardiomyopathy?"
  </Accordion>

  <Accordion title="Literature" icon="newspaper">
    Search published literature and preprints on genes, mechanisms, methods, targets, and therapies.

    **Example queries:**

    * "What recent research exists on PTEN mutations in cancer?"
    * "Find papers on de novo variants in autism."
    * "Summarize the latest work on senolytics in pulmonary fibrosis."
  </Accordion>

  <Accordion title="Pathways and proteins" icon="network-wired">
    Explore pathways, protein function, structures, domains, PTMs, and interaction context.

    **Example queries:**

    * "Which pathways involve CFTR?"
    * "Map EGFR resistance mechanisms to downstream signaling."
    * "Show structural context for this UniProt residue."
  </Accordion>

  <Accordion title="Drug and target databases" icon="capsules">
    Query compound-target relationships, target-disease associations, pharmacology, and drug-gene knowledge.

    **Example queries:**

    * "What compounds target MET exon 14 skipping?"
    * "Compare Open Targets evidence for JAK1 and TYK2 in psoriasis."
    * "What pharmacogenomic evidence exists for DPYD?"
  </Accordion>
</AccordionGroup>

## How it works

Describe what you need in natural language. Purna determines which sources to query, gathers evidence, and synthesizes the result. A single response may combine database records, literature, pathway data, and web results.

## Controlling sources and tools

Open **Preferences** in the chat input to control active capabilities and knowledge sources. Use this when you want to focus a conversation on literature, database evidence, code execution, or other tool families.

## Citations and evidence tracking

Purna includes source identifiers as clickable citation badges when evidence is available. These can include PubMed IDs, ClinVar accessions, OMIM records, dbSNP identifiers, UniProt entries, or web sources.

Click citation badges to inspect the source record directly.

<Note>
  Always verify important scientific or clinical information against authoritative sources before making decisions. Purna aggregates and synthesizes evidence, but definitive interpretation should come from qualified experts and primary records.
</Note>