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Frequently Asked Questions

No. You can interact with Purna entirely through natural language. However, if you’re familiar with Python, you can ask Purna to write and run custom scripts directly in your browser using Pyodide with pandas, matplotlib, and seaborn.
Agent Mode is a chat-first interface for general genomics questions and database searches — no patient context needed.Case Mode is for managing patient cases with variant data, phenotypes, and clinical findings. Toggle between modes using the buttons in the top-right corner.
Purna requires VCF (Variant Call Format) files. Upload during case creation by dragging and dropping or using the Upload VCF button.
Your data is securely stored. Conversations and case data are private by default. You control visibility with the lock icon for conversations and the Access tab for cases. Code execution runs in your browser via Pyodide — data never leaves your session.
Yes. In Agent Mode you can search genomic databases, research genes and diseases, build gene panels, and generate visualizations — all without patient data.
Gene panels are curated gene lists for targeted variant filtering. Create custom panels or search existing ones, then apply them from chat (“Find variants in my cardiomyopathy panel”) or from the Virtual Panels filter in the Variants tab.
Yes. In any case, go to the Access tab to add team members with Admin or General roles. Manage broader team settings from Settings > Team.
Click any variant in the variant browser to open a detail panel with seven tabs: Assessment (in silico predictions), Details (genomic location, HGVS, population frequencies), Research (ClinVar, PubMed, gene info), ACMG (classification criteria), gnomAD (population data browser), AI Analysis (AI-powered interpretation), and Notes (collaborative annotations).
The ACMG tab in the variant detail panel shows the 28 standard ACMG/AMP criteria. Use AI Enhance to have Purna automatically evaluate criteria using ClinVar, PubMed, gnomAD, and functional data. Review suggestions, accept or reject individual criteria, and manually reclassify with Reclassify. All changes are tracked in the reclassification history.
Five report types: variant interpretation, clinical findings, case summary, ACMG evidence, and variant comparison. Ask from chat (e.g., “Generate a case summary report”) and Purna creates the document in the artifacts panel for download.
Findings are variants marked as clinically significant during analysis. Categorize each as Primary (explains phenotype), Causal (confirmed cause), Secondary (related but not primary), or Incidental (unrelated but actionable). View and export findings from the Findings tab.
HPO (Human Phenotype Ontology) phenotypes describe a patient’s clinical features. Add them via AI Assist (Purna suggests terms from clinical descriptions) or Search (manual lookup). Phenotypes become powerful filters in the Variants tab as Primary or Secondary Phenotypes.
The Settings tab lets you rename the case, edit case details, upload and manage files, view the settings activity audit log, and archive the case from the Danger Zone section.
Pie/donut, bar, horizontal bar, line, and area charts. Describe the visualization you want in natural language and Purna generates it. After generation, ask to adjust colors, labels, or chart type.
Purna runs Python in your browser through Pyodide. Available libraries: pandas, matplotlib, and seaborn. Your data stays in your session and never leaves your machine.
Cases that haven’t been accessed recently may be archived for performance. When you open one, Purna retrieves and loads it. This is typically brief.
Yes. Export findings from the Findings tab, generate clinical reports from chat, create spreadsheet artifacts (CSV), and save Python scripts. Reports appear as downloadable artifacts in the side panel.
Three tiers: Individual (50/month,50queries/day),∗∗Pro∗∗(50/month, 50 queries/day), **Pro** (125/month, API access, background analysis), and Team ($999/month, unlimited queries, SSO, custom branding, unlimited members). Manage from Settings > Plan.
Go to Settings > General > Personalization and configure Base Style (Detailed/Concise), Tone (Professional/Casual), Characteristics (Balanced/Cautious/Confident), and Output Format (Structured/Conversational).
Currently Single Inherited Disease. Family Inherited Disease and Somatic Case types are coming soon.
Responses include inline citation badges (ClinVar, NCBI, PubMed, etc.) that link directly to source records. Click any badge to verify the information.
Go to Settings > Team and click Invite to generate an invitation link. Share the link with your colleagues. They can create an account (if needed) and join your organization through the link.