Starting a conversation
Click the + button in the top bar to start a new chat. The home screen displays suggested prompts to get you started, such as “Find pathogenic variants in BRCA1 and BRCA2 genes.” Click any suggestion or type your own question directly into the chat input.
Switching between Agent Mode and Case Mode
Toggle buttons in the top-right corner switch between Agent Mode and Case Mode. Agent Mode is a chat-first experience for general genomics queries. No patient context is needed — use it to research genes, diseases, variants, and clinical implications. Case Mode opens the case management view and displays your patient cases. Switch between modes at any time depending on your workflow.Working with patient case context
To analyze data from a specific patient, use the Cases dropdown at the bottom of the chat input. Select a patient case and Purna scopes its queries to that patient’s variant data. Once a case is selected, you can ask questions like:- “What are the likely pathogenic variants in this case?”
- “Find loss-of-function variants in BRCA1”
- “Are there any ClinVar pathogenic variants in the cardiac gene panel?”
Without a case selected, Purna answers general genomics questions and searches public databases but cannot access patient-specific variant data.
Selecting research sources
Control which databases Purna searches using the Sources dropdown next to the Cases dropdown. The counter (e.g., “5/5”) shows how many source categories are active. Click Sources to open the panel with five toggleable categories:| Category | Databases |
|---|---|
| Research Papers | PubMed, Nature, Cell, NEJM, Lancet, arXiv, bioRxiv |
| Clinical Evidence | ClinVar, ClinicalTrials, OMIM, ClinGen, Orphanet |
| Variant Databases | gnomAD, GWAS Catalog, dbSNP, VarSome, Franklin |
| Guidelines | ACMG, NCCN, UpToDate, CDC, WHO |
| Drugs & Therapies | PharmGKB, DrugBank, FDA, ClinicalTrials |
Types of questions you can ask
Variant queries
Variant queries
With a case selected, ask about specific variants — classification, pathogenicity, clinical significance, allele frequencies, and functional impacts. Example: “What is the clinical significance of CFTR c.1521_1523delCTT?”
Gene and disease lookups
Gene and disease lookups
Research genes and their associated diseases, clinical significance, and known variants. Example: “What genes are associated with cardiomyopathy?”
Analysis and visualization
Analysis and visualization
Request aggregations, statistics, and charts from your data. Example: “Create a bar chart of variants per gene in my case.”
Reports and documents
Reports and documents
Generate clinical reports, variant summaries, and other structured documents. Example: “Generate a variant interpretation report for the pathogenic findings.”
AI tool usage indicators
When Purna uses a tool to query a database, a status indicator appears above the response showing which tool was used and the result count:- “Variant Annotation — Found 20 variants”
- “PubMed — Found 15 papers”
- “MyGene.info — Found gene information”
Citations and references
Responses include inline citation badges linking to original sources. Badges are color-coded by database — click any badge to open the source record in a new tab and verify the information.
Always verify clinical findings by clicking citation badges to review the original source data.
Managing chat history
The sidebar displays past conversations organized by Today, Yesterday, and Last 7 days. Use the search bar at the top to find conversations by keyword. Click any conversation to resume it. Hover over a conversation to reveal a three-dot menu with options to rename or delete it. Use the trash icon in the top bar to manage multiple chats.Chat visibility
The lock icon with a dropdown arrow in the top bar controls conversation visibility. Click it to toggle between private and shared visibility for your current conversation.Attaching files
Click the paperclip icon next to the send button to attach files to your message. You can share genomic files, documents, or other relevant data for Purna to analyze.Providing feedback
Each response includes feedback options:- Copy: Copy the response text to your clipboard
- Thumbs up: Mark the response as helpful
- Thumbs down: Mark the response as unhelpful
Working with artifacts
During conversations, Purna may create artifacts — documents, code files, or spreadsheets — that appear in a side panel alongside your chat. Artifacts are versioned with built-in change tracking. You can generate three types of artifacts:- Text documents: Clinical summaries, variant reports, case notes
- Code files: Reusable Python scripts
- Spreadsheets: Tabular data in CSV format