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Purna connects to major genomic databases so you can look up genes, variants, diseases, and literature without leaving the conversation. Ask your question naturally, and Purna queries the right databases automatically.

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Supported databases

Query gene function, transcript information, protein annotations, and pathway relationships.Example queries:
  • “What’s the function of the BRCA1 gene?”
  • “Show me the known transcripts for TP53”
  • “Which pathways involve the CFTR gene?”
Search for clinical significance of specific variants, including interpretation classifications and assertion criteria.Example queries:
  • “What’s the clinical significance of BRCA1 c.68_69delAG?”
  • “Show variants in ClinVar marked as pathogenic for cystic fibrosis”
  • “Is this variant in ClinVar?”
Explore disease-gene associations, inheritance patterns, clinical features, and phenotypic descriptions.Example queries:
  • “Which genes cause Marfan syndrome?”
  • “What’s the inheritance pattern of familial hypercholesterolemia?”
  • “Tell me about the clinical features of Duchenne muscular dystrophy”
Look up SNP identifiers, minor allele frequencies, and variant functional annotations.Example queries:
  • “What do you know about rs1234567?”
  • “Show me common variants in the APOE gene”
  • “What’s the population frequency of this SNP?”
Search published literature and research articles on genes, variants, diseases, and therapies.Example queries:
  • “What recent research exists on PTEN mutations in cancer?”
  • “Find papers on de novo variants in autism”
  • “What does the literature say about penetrance of BRCA mutations?”

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How it works

Describe what you’re looking for in natural language. Purna understands the context and automatically queries the appropriate databases. You’ll often get results from multiple sources in a single response — for instance, asking about a gene might return functional information, disease associations, and relevant publications.

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Research sources panel

Control which databases Purna searches using the Sources dropdown at the bottom of the chat:
CategoryDatabases
Research PapersPubMed, Nature, Cell, NEJM, Lancet, arXiv, bioRxiv
Clinical EvidenceClinVar, ClinicalTrials, OMIM, ClinGen, Orphanet
Variant DatabasesgnomAD, GWAS Catalog, dbSNP, VarSome, Franklin
GuidelinesACMG, NCCN, UpToDate, CDC, WHO
Drugs & TherapiesPharmGKB, DrugBank, FDA, ClinicalTrials
Toggle sources on or off based on your research needs.

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Citations and evidence tracking

Purna includes database identifiers in responses as clickable badges — ClinVar accession numbers, PubMed IDs, OMIM gene symbols, and dbSNP accessions. Click any badge to open the source record and verify information independently. For information beyond specialized genomic databases, Purna can query the broader web. For example: “What are the latest clinical trials for spinal muscular atrophy?”
Always verify clinical information against authoritative sources before making clinical decisions. Purna aggregates information from multiple databases, but definitive interpretation should come from specialists and official clinical guidelines.