Skip to main content
Get up and running with Purna in just a few minutes. You’ll learn how to sign in, explore Agent Mode for genomics queries, and switch to Case Mode for patient case management.

​
Sign in to Purna

1

Open Purna

Navigate to mip.purna.ai in your web browser.
2

Sign in

Enter your Purna credentials. If you don’t have an account, contact your organization administrator or use an invitation link if one was shared with you.
3

View the home screen

After signing in, you’ll see the Purna home screen in Agent Mode with suggested prompts to get started.Purna home screen

​
Start chatting in Agent Mode

Agent Mode is your entry point to Purna. Use natural language to ask questions about genes, variants, diseases, and clinical implications.
1

Choose a suggested prompt

The home screen offers helpful starting points. Click any suggestion to begin, such as:
  • “Find pathogenic variants in BRCA1 and BRCA2 genes”
  • “What are the clinical implications of a VUS in TP53?”
2

Or type your own question

Click in the chat input box and type your question. For example:
  • “Which genes are associated with hereditary breast cancer?”
  • “What does ClinVar say about EGFR p.Val397Met?”
3

View the response

Purna returns evidence-based answers with citations from genomic databases. Tool usage indicators show which databases were queried and how many results were found.
Purna understands genomics terminology and context, so natural language queries work best. You can ask complex, multi-part questions.

​
Switch to Case Mode

Case Mode lets you work with patient-specific data. Switch from Agent Mode to Case Mode using the toggle in the top-right corner.
1

Enable Case Mode

Click Case Mode in the top-right corner of the interface.
2

View your cases

You’ll see a list of your existing patient cases sorted by recent activity. Use the search bar to find specific cases.Cases list

​
Create a new case

1

Click + New Case

In Case Mode, click the + New Case button to open the case creation dialog.
2

Fill in case details

Complete the required fields:
FieldDescription
Case NameIdentifier for the case (e.g., “Patient_12345”)
Case TypeSingle Inherited Disease (Family and Somatic coming soon)
ConsanguinityWhether the patient has consanguineous parents
SexPatient biological sex
Date of BirthPatient DOB
EthnicityPatient ethnicity for allele frequency context
Secondary FindingsOpt-in to report incidental findings in medically actionable genes
3

Add sample information

Enter order number, collection and received dates, specimen type, ordering physician, and ordering institution.
4

Upload genomic data

Upload a VCF (Variant Call Format) file containing the patient’s genomic variants. Drag and drop or click Upload VCF to select your file.
5

Create the case

Click Create to save the case. Purna processes your VCF file and prepares the case for analysis.

​
Explore case tabs

Once you’ve opened a case, navigate between six tabs:

Overview

Dashboard with pathogenicity distribution, variant location, read depth charts, and findings summary.

Findings

Curated variants of interest categorized as Primary, Causal, Secondary, or Incidental.

Phenotypes

Manage HPO phenotypes with AI Assist or manual search.

Variants

Browse and filter variants in cards or table view with gene panels and phenotype filters.

Access

Control who can view and edit this case within your organization.

Settings

Rename, upload files, view audit log, and archive the case.

​
Ask contextual questions

1

Select a case from the chat

In the chat input area, click the Cases dropdown and select the patient case you want to ask about.
2

Ask case-specific questions

Your queries are now scoped to that patient’s data. Examples:
  • “What are the top pathogenic variants in this patient?”
  • “Find loss-of-function variants in BRCA1”
  • “Which variants have ClinVar pathogenic classifications?”
You can switch between cases at any time by changing the Cases dropdown selection. Your chat history persists across cases.

​
What’s next?

AI chat

Master natural language queries, research sources, and artifacts.

Variant analysis

Browse and filter variants with the full variant browser.

ACMG classification

AI-enhanced variant classification with ACMG/AMP criteria.

Gene panels

Build virtual gene panels for targeted analysis.